Source: Ranked + player metaPatch: 16.17Window: patchRegion: allRank: emerald_plusQueue: ranked_soloSample: 36Updated 10/28/2026, 9:46:13 AM
Confidence: Medium-5.6% vs 50%36 games
Lane phases
AI heuristicLevels 1–2
Vayne edge
Vayne has stronger early trades — respect all-ins.
Levels 3–5
Vayne edge
Miss Fortune needs to play safe until item spikes.
Level 6+
Vayne edge
Ultimate timing often swings the next two waves.
Mid / late
Vayne edge
If Miss Fortune reaches items, teamfights can neutralize the lane loser.
Why?
AI heuristicHard
- Sample win rate for Miss Fortune is 44.4% in this matchup.
- Vayne statistically wins more often in the current Emerald+ sample.
Treat this as a Hard matchup for Miss Fortune into Vayne — prioritize cooldown windows and jungle tracking.
Do
- Give up early shove if Vayne can all-in you.
- Track summoner spells and ultimate cooldowns before committing.
- Play for wave states that let you crash and reset safely.
Don't
- Don't overstay for a plate when behind.
- Don't force extended trades when key abilities are down.
- Don't ignore jungle timers when the lane is volatile.
Matchup build callout
Full builds →Most-played Miss Fortune page (ADC): Press the Attack Build · 46.2% WR · 119 games
Skill order: Q › W › E
Keystones (player meta)
Most common keystones when miss-fortune faces vayne in lookup-discovered matches.
First Strike3G66.7%
Press the Attack2G100.0%
Patch: 16.17Region: naRank: emerald_plusQueue: ranked_soloSample: 216Updated 10/22/2026, 1:02:15 PM