Source: Ranked + player metaPatch: 16.17Window: patchRegion: allRank: emerald_plusQueue: ranked_soloSample: 54Updated 10/28/2026, 4:36:40 AM
Confidence: High-3.7% vs 50%54 games
Lane phases
AI heuristicLevels 1–2
Lissandra edge
Lissandra has stronger early trades — respect all-ins.
Levels 3–5
Lissandra edge
Karthus needs to play safe until item spikes.
Level 6+
Lissandra edge
Ultimate timing often swings the next two waves.
Mid / late
Even
If Karthus reaches items, teamfights can neutralize the lane loser.
Why?
AI heuristicHard
- Sample win rate for Karthus is 46.3% in this matchup.
- Lissandra statistically wins more often in the current Emerald+ sample.
Treat this as a Hard matchup for Karthus into Lissandra — prioritize cooldown windows and jungle tracking.
Do
- Give up early shove if Lissandra can all-in you.
- Track summoner spells and ultimate cooldowns before committing.
- Play for wave states that let you crash and reset safely.
Don't
- Don't overstay for a plate when behind.
- Don't force extended trades when key abilities are down.
- Don't ignore jungle timers when the lane is volatile.
Matchup build callout
Full builds →Most-played Karthus page (ADC): Deathfire Touch Build · 58.4% WR · 125 games
Skill order: Q › E › W
Patch: 16.17Region: naRank: emerald_plusQueue: ranked_soloSample: 162Updated 10/22/2026, 1:02:15 PM