Source: Ranked + player metaPatch: 16.17Window: patchRegion: allRank: emerald_plusQueue: ranked_soloSample: 45Updated 10/28/2026, 4:36:29 AM
Confidence: Medium-1.1% vs 50%45 games
Lane phases
AI heuristicLevels 1–2
Even
Karthus and Kassadin trade evenly before spikes.
Levels 3–5
Kassadin edge
Play around ability cooldowns and wave control.
Level 6+
Kassadin edge
Ultimate timing often swings the next two waves.
Mid / late
Even
Side-wave and vision decide more than the raw lane matchup.
Why?
AI heuristicEven
- Sample win rate for Karthus is 48.9% in this matchup.
Treat this as a Even matchup for Karthus into Kassadin — prioritize cooldown windows and jungle tracking.
Do
- Track summoner spells and ultimate cooldowns before committing.
- Play for wave states that let you crash and reset safely.
Don't
- Don't force extended trades when key abilities are down.
- Don't ignore jungle timers when the lane is volatile.
Matchup build callout
Full builds →Most-played Karthus page (ADC): Deathfire Touch Build · 58.4% WR · 125 games
Skill order: Q › E › W
Patch: 16.17Region: naRank: emerald_plusQueue: ranked_soloSample: 162Updated 10/22/2026, 1:02:15 PM