MidTopADCManaTier A

Cassiopeia

the Serpent's Embrace

Mage

Win Rate

50.9%

Pick Rate

4.6%

Ban Rate

0.0%

Sample

291

Source: Ranked + player metaPatch: 16.17Window: patchRegion: allRank: emerald_plusQueue: ranked_soloSample: 44Updated 10/28/2026, 6:36:27 PM
Confidence: Medium+6.8% vs 50%44 games

Cassiopeia

VS

56.8%

44 games · character advantage

Karma

Lane phases

AI heuristic

Levels 1–2

Cassiopeia edge

Cassiopeia can look for early pressure.

Levels 3–5

Cassiopeia edge

Convert leads before Karma scales or roams.

Level 6+

Cassiopeia edge

Ultimate timing often swings the next two waves.

Mid / late

Cassiopeia edge

Close out with vision and objective control.

Why?

AI heuristic

Favored

  • Sample win rate for Cassiopeia is 56.8% in this matchup.
  • Cassiopeia is favored in the current Emerald+ sample.

Treat this as a Favored matchup for Cassiopeia into Karma — prioritize cooldown windows and jungle tracking.

Do

  • Look for crash + roam when you hit a spike.
  • Track summoner spells and ultimate cooldowns before committing.
  • Play for wave states that let you crash and reset safely.

Don't

  • Don't throw the lead diving without vision.
  • Don't force extended trades when key abilities are down.
  • Don't ignore jungle timers when the lane is volatile.

Matchup build callout

Full builds →

Most-played Cassiopeia page (Mid): Deathfire Touch Build · 51.3% WR · 261 games

Skill order: E › Q › W

Patch: 16.17Region: naRank: emerald_plusQueue: ranked_soloSample: 291Updated 10/22/2026, 1:02:15 PM